Endocrine Abstracts

Macroprolactin (MPL) is a complex of prolactin (PRL) and IgG. It is considered to have little bioactivity and may account for a significant proportion of patients with 'idiopathic hyperprolactinaemia'. We determined the prevalence of macroprolactinaemia in patients with hyperprolactinaemia and examined the clinical features. An Immuno-1 system with PEG precipitation was used to identify MPL, with a recovery of <50% taken as indicating significant macroprolactinaemia.In ...

Background: Neuroendocrine tumors (NETs) are increasing in incidence and prevalence. Small intestine, rectum, pancreas and appendix are the most common enteric sites of NETs, and when identified early, surgical resection can be curative. We hypothesized that observed increases in incidence and prevalence of NETs are primarily driven by earlier detection of loco-regional tumors. In turn, increases in incidence of early-stage tumors is associated with increases in resection and ...